The first Italic peoples to endure Roman expansionism outside of Latium were the Etruscans, just as the Carthaginians were the first people outside of the italian peninsula to face the imperialism of Rome.
Rome began its attacks on Etruria in approximately 498 BCE and concluded in 264 BCE with the complete conquest of Etruria. They endured a total of 234 years varying between conflicts, counter attacks, reprisals and truces - an extremely long period of time.
United Etruria was militarily more powerful and and more populous than Rome but the religious alliance of the twelve did not extend to mutual political or military support.
The Etruscan league cities of this period faced their Roman adversary either on their own
or in partial groupings, but never all united. Secondly, in these 234 years Etruscan politics were in damage control mode, and were preoccupied with the politics of aggression. The Etruscans felt that they were too strong to succumb to Rome which for that moment was engaged with the Samnites of Southern Italy.
Nothing that happened subsequently was to change their attitude- neither the death throes of their naval supremacy (The beginning of the end was their defeat at Cumae in 474 BCE) nor the loss of the Po Valley League to the Celts.
Inexplicably, the two other thalassocratic Queens of the Tyrrhenian Sea and the western Mediterranean, namely the Greeks of Syracuse and the Punic peoples of Carthage were to stand by and watch the systematic defeat of Etruria. They saw in this the elimination of an old military adversary, and above all the demise of a commercial seafaring contender. They failed to comprehend that their own territories would be the next conquest for the invincible Roman legions.
The Roman campaign against Carthage began in 264 BCE and would take 3 wars and 118 years of bloody conflict to finally gain victory over the City of Dido in 146 BCE. Carthage had less of a population to draw on than Etruria and hired the military service of mercenaries (Celts) and troops from subjugated populations (the Iberians, the Balearics, Libyans and Numidians), but Carthage was united and politically focussed, it was rich, and technologically advanced from the remnants of its own past expansionism, analagous to that of Rome.
All that did not save it from its eventual ruin and departure from the scene of the ancient world. The attitude of Rome against Etruria is worthy of consideration It is true that by romanisation the language and religion of Etruria were slowly eroded away- but this was a gradual and continuous process.
Indeed in a way it could be said that Rome had a regard for the Etruscans - a regard that they did not have for Syracuse or Carthage, both of which were destroyed by Rome. In my humble opinion, Rome knew that its civilization owed a great deal to Etruria : The Servian walls, the Cloaca Maxima , the arts of divinatation and haruspicy, the Sibylline books, Lictors rods, Education and the cultural training in Caere of Roman youth. It could not destroy the genius of the Etruscans that dwelt within themselves and this inevitably delayed their final end, until the time that according to Tagetes would end in 54 CE, (the death of the Emperor Claudius) with the end of the 10th saeculum granted by the gods to the life of the Etruscan nation: